F5 Networks shares fell 6 percent at $100.75 in extended trade, after closing at $107.54 on Wednesday on the Nasdaq.
Anderson joined F5 in 2004 and was overseeing all sales activities for the company's application delivery networking product and service portfolio.
"Mark was a key contributor to our growth and success here at F5," Chief Executive John McAdam said in a statement.
F5's revenue has grown in the double-digits for more than two years as a booming market for smartphones and tablets has sparked an exponential increase in data traffic.
(Reporting by Supantha Mukherjee in Bangalore; Editing by Viraj Nair)
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