"It's a very opportunity-rich environment right now," said Marc Andreessen, the firm's co-founder, who said the firm planned to stick to its strategy of investing in companies with the potential to upend an industry, often around the software theme, which he sees playing out for some time.

"After software, there will be more software," said Andreessen, who cited industries such as book publishing that were relatively unaffected by software changes until innovations such as Amazon's Kindle and Apple's iPad emerged in recent years.

Next up would be industries such as healthcare and education, he said.

In a blog post, co-founder Ben Horowitz said last year the firm hosted 600 portfolio presentations to help introduce its start-ups to potential customers at Fortune 500 companies.

Separately, the firm has made introductions that have helped its start-ups recruit 130 new staffers in a tough-to-hire environment in Silicon Valley, particularly for engineers.

Andreessen Horowitz started with $300 million in 2009 and then raised $900 million more in 2010. It has invested in many of the country's hottest start-ups, including Airbnb, Pinterest, Zynga and Facebook, which is preparing for a much-anticipated initial public offering.

Raising $1.5 billion in a single fund places it in a relatively elite group of billion-plus funds.

(Reporting By Sarah McBride; Editing by Phil Berlowitz)

• A Permanent Economic Emergency