April-June net loss narrowed to $5.5 million, or 15 cents per share, from $9.5 million, or 27 cents per share, a year earlier.
Revenue, which Medivation generates mostly through collaborations with Astellas Pharma Inc, more than doubled to $42.9 million, boosted by $35.6 million of deferred revenue from ending a drug development deal with Pfizer Inc.
Pfizer and Medivation stopped developing a potential Alzheimer's drug in January after it failed to show efficacy in a late-stage study.
Medivation's operating expenses rose 67 percent to $43.9 million for the second quarter.
The company said it expects to recognize the remaining $5.5 million of deferred revenue from ending its deal with Pfizer in the third quarter.
Medivation's shares closed at $98.42 on the Nasdaq on Thursday. They fell to $95.50 in extended trading.
(Reporting by Zeba Siddiqui in Bangalore; Editing by Joyjeet Das)
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