The British company has started reaching out to executives in the pharmaceutical industry as well as finance and governance experts who could be nominated as independent directors on Human Genome's 12-member board, they said.

GSK now intends to seek consent from Human Genome shareholders to replace the entire board and the consent solicitation process could come in the next few weeks, the sources said. GSK is also expected to extend its tender offer for Human Genome beyond June 7, added the sources, who asked not to be named because the matter is not public.

The move, which GSK had flagged as a possibility in a regulatory filing earlier this month, could send yet another signal to potential bidders of the seriousness of GSK's desire to buy Human Genome. This might make it harder for the U.S. biotech company to find a white knight willing to take on the UK pharma giant.

Healthcare bankers say GSK has an advantage over rivals to buy Human Genome because the two have existing partnerships around key drugs. The two companies together sell Benlysta, a new drug for the autoimmune condition known as lupus. They also collaborate on two other experimental drugs for diabetes and heart disease, currently in late-stage trials, that could become significant sellers. GSK owns the vast majority of the potential commercial gains associated with these drugs.

Human Genome has rejected the bid as inadequate and launched an auction process, inviting GSK to participate. The biotech company has also adopted a shareholder rights plan in a bid to thwart the hostile takeover attempt.

"GSK declined to enter the process and, through its offer, seeks to circumvent, disrupt and prematurely end the company's process to the disadvantage of (Human Genome) stockholders," a Human Genome spokesman said.

GSK declined to comment.

PERSUADING INVESTORS

GSK took its offer directly to Human Genome's shareholders earlier this month after being spurned, and one of the sources said GSK was feeling increasingly confident that shareholders would come around to its offer.

"The debate is about when HGS shareholders start to apply pressure to HGS management to give them the option to consider this offer," the source said, referring to Human Genome.

But the UK company may have more work to do in persuading investors that its $13-per-share bid is good enough. Shares of Human Genome were trading down about 1 percent at $13.69 on the Nasdaq, 5 percent above GSK's offer, indicating that investors expect a higher price.

Complicating matters further is the shareholder base of Human Genome - the top 10 shareholders owned more than 75 percent of the company as of the end of last quarter.

A Human Genome shareholder has filed a lawsuit against the board and asked a Maryland court to temporarily restrain the company from using the poison pill.

(Reporting By Soyoung Kim and Paritosh Bansal in New York, and Ben Hirschler in London; Editing by Gerald E. McCormick, John Wallace and Matthew Lewis)

• A Permanent Economic Emergency