Mylan had admitted that its product would infringe the patent, which run until April of 2017, Merck said.
Merck earlier on Friday said first-quarter sales of Zetia, known chemically as ezetimibe, rose 6 percent to $614 million, while Vytorin, which combines Zetia with Merck's older cholesterol drug Zocor, saw sales slip 8 percent to $444 million.
In a ruling in U.S. District court for the district of New Jersey, Judge Jose Linares declared the patent to be "valid and enforceable."
(Reporting By Bill Berkrot)
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