MSNBC.com was renamed NBCNews.com and users were automatically redirected to the new website.
NBC and Microsoft joined forces in 1996 to create a cable news channel and online news operation that melded broadcasting with then-emerging internet technology.
The news of a possible buyout was first reported in May.
"MSNBC TV will launch a new digital home in 2013, as an extension of the MSNBC TV on-air brand," the editor-in-chief of MSNBC.com wrote in a letter posted on MSNBC website.
Comcast and Microsoft could not be immediately reached for comment by Reuters outside regular U.S. business hours.
(Reporting by Adithya Venkatesan in Bangalore; Editing by Muralikumar Anantharaman)
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