Warner Bros Television, which syndicates "Anderson", said on Monday the show will not be renewed after the current season ends in the summer of 2013.
"The series will not be coming back for a third season in a marketplace that has become difficult to break through," Warner Bros said in a statement.
The CNN anchor launched "Anderson," subsequently retitled "Anderson Live," in September 2011. But the show has struggled in the ratings despite retooling in the face of competition from veteran daytime hosts such as Ellen DeGeneres, and newcomers such as Katie Couric and "Survivor" host Jeff Probst.
"Anderson Live," is attracting an average audience of about 1.4 million viewers, compared with around 4 million for "Dr. Phil" and about 2.3 million for "Katie," according to TV ratings data.
Cooper issued a statement on Monday saying, "I am very proud of the work that our terrific staff has put into launching and sustaining our show for two seasons," and added that he looked forward "to doing more great shows this season ... I'm sorry that we won't be continuing."
TV stations carrying the show were first informed on Friday that the producers were not seeking renewal for another season.
Cooper, 45, and the winner of multiple Emmy award and a Peabody Award, continues as host of the CNN news program "Anderson Cooper 360" and has hosted the network's New Year's Eve special from Times Square for several years running.
Warner Bros is owned by Time Warner Inc.
(Reporting by Chris Michaud, editing by Jill Serjeant and Marguerita Choy)
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