Dame Helen will star in Peter Morgan's "The Audience," opening in London in 2013. The play traces 60 years of weekly "audiences" or meetings at Buckingham Palace between the British monarch and her prime ministers.
Britain has had 12 prime ministers during Queen Elizabeth's 60-year reign, and the play imagines some of the pivotal private meetings that took place as the Queen, who ascended to the throne at age 25, grew from young womanhood to elder stateswoman, producers said in a statement.
Stephen Daldry, the man behind the stage musical and movie "Billy Elliot," will direct.
Morgan won was Oscar-nominated for his screenplay for 2006 movie "The Queen," which traced royal and political reaction to the sudden death in a car crash in 1997 of Princess Diana.
Mirren, 67, won an Oscar, a Golden Globe, a Screen Actors Guild award and a British BAFTA for her portrayal of the Queen. She also won a raft of awards from playing Queen Elizabeth I in the 2005 British television series "Elizabeth I."
"The Audience" will open in previews at London's Gielgud Theatre on Feb 15, 2013, and is scheduled to run until June.
(Reporting By Jill Serjeant in Los Angeles; editing by Gunna Dickson)
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