The Santa Clara, California, company is implementing a voluntary retirement program and other measures to eliminate between 900 and 1,300 positions, it said in a statement on Wednesday.
Hurt by slow economies, tepid PC shipments and declining sales in its non-core display and solar businesses, Applied Materials warned in August that its revenue would fall more than expected by analysts.
The company has assigned Gary Dickerson, recently appointed president of Applied Materials, to review the effectiveness of its investments in its different businesses.
That could lead Applied Materials to get out of its non-core markets to focus on developing more competitive chip manufacturing gear, some analysts said.
"This is a strong indicator that Gary Dickerson is starting to exert his influence in the company," said Stifel Nicolaus analyst Patrick Ho. "I think this is the initial move. I don't think this is then the only move."
By the time the cuts are implemented in the third quarter of fiscal 2013, they should save between $140 million and $190 million annually, Applied Materials said.
The company expects to record a pre-tax restructuring charge of between $180 million and $230 million. It will begin recording the charges in the fourth quarter of fiscal 2012, with the remainder during fiscal 2013.
Dickerson was previously Chief Executive of Varian Semiconductor Equipment Associates, which Applied Materials bought in 2011.
Applied Materials' stock was unchanged in after hours trading after closing down 0.09 percent at $11.16.
(Reporting by Chandni Doulatramani in Bangalore; Editing by Sriraj Kalluvila and Andre Grenon)
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