Los Angeles-based agent Jackie Stander confirmed reports that Pallilo, 63, died on Tuesday morning.
Celebrity news website TMZ.com reported that Pallilo died of an apparent heart attack at his home near Palm Beach, Florida.
Pallilo, whose character was known for the catch-phrase "Ooh-ooh-ooooh!", played Horshack for four years in the 1975-79 ABC comedy, which also starred John Travolta.
The show captured the antics of an unruly group of remedial high school students and their wise-cracking teacher Gabe Kotter, played by comedian Gabe Kaplan.
(Reporting By Jill Serjeant; editing by Carol Bishopric)
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